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《医学前沿(英文)》 2013年 第7卷 第2期 页码 264-269 doi: 10.1007/s11684-013-0259-1
The effect of the severity of appendiceal inflammation on post-operative stay in children following appendicectomy has shown conflicting results. This study was conducted to determine the association between the severity of appendiceal inflammation and post-operative stay amongst children undergoing open appendicectomy. A retrospective cohort study was conducted at a District General Hospital for two years. A total of 204 patients were included in the study with an age range between 3 and 16 years. Females were 54.9% while the rest were male. Mean age was 12.5±3 years. The association of the severity of appendiceal inflammation and post-operative stay was assessed by multivariable Cox Proportional hazards model. Mean post-operative stay was 2.32 days (95% CI 2.14–2.51). Macroscopically perforated appendix, histological inflammation and post-operative complications were significantly associated with post-operative stay on univariable analysis (P<0.05). Whereas, the multivariable analysis showed that the post-operative stay was significantly prolonged only in case of either perforated appendix or post-operative complications while it remained unaffected by the histological inflammation.
关键词: appendiceal inflammation post-operative stay paediatrics
《工程管理前沿(英文)》 页码 577-591 doi: 10.1007/s42524-022-0203-7
关键词: nursing home predictive analytics individualized prediction competing risks health outcomes
Severe adhesive small bowel obstruction
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《医学前沿(英文)》 2012年 第6卷 第4期 页码 436-439 doi: 10.1007/s11684-012-0221-7
Adhesive small bowel obstruction is a frequent cause of hospital admission. Water soluble contrast studies may have diagnostic and therapeutic value and avoid challenging demanding surgical operations, but if bowel ischemia is suspected, prompt surgical intervention is mandatory. A 58-year-old patient was operated for extensive adhesive small bowel obstruction after having had two previous laparotomies for colorectal surgery, and had a complex clinical course with multiple operations and several complications. Different strategies of management have been adopted, including non-operative management with the use of hyperosmolar water soluble contrast medium, multiple surgical procedures, total parenteral nutrition (TPN) support, and finally use of anti-adherences icodextrin solution. After 2 years follow-up the patient was doing well without presenting recurrent episodes of adhesive small bowel obstruction. For patients admitted several times for adhesive small bowel obstruction, the relative risk of recurring obstruction increases in relation to the number of prior episodes. Several strategies for non-operative conservative management of adhesive small bowel obstruction have already addressed diagnostic and therapeutic value of hyperosmolar water soluble contrast. According to the most recent evidence-based guidelines, open surgery is the preferred method for surgical treatment of strangulating adhesive small bowel obstruction as well as after failed conservative management. Research interest and clinical evidence are increasing in adhesions prevention. Hyaluronic acid-carboxycellulose membrane and icodextrin may reduce incidence of adhesions.
关键词: post-operative intraperitoneal adhesions adhesive small bowel obstruction adhesiolysis antiadhesion treatments hyperosmolar water soluble contrast medium
Vortex-induced vibration of stay cable under profile velocity using CFD numerical simulation method
Wenli CHEN, Hui LI,
《结构与土木工程前沿(英文)》 2009年 第3卷 第4期 页码 357-363 doi: 10.1007/s11709-009-0060-z
关键词: stay cable fluid-structure interaction numerical simulation vortex-induced vibration
Emergency strategies and trends in the management of liver trauma
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《医学前沿(英文)》 2012年 第6卷 第3期 页码 225-233 doi: 10.1007/s11684-012-0186-6
The liver is the most frequently injured organ during abdominal trauma. The management of hepatic trauma has undergone a paradigm shift over the past several decades, with mandatory operation giving way to nonoperative treatment. Better understanding of the mechanisms and grade of liver injury aids in the initial assessment and establishment of a management strategy. Hemodynamically unstable patients should undergo focused abdominal sonography for trauma, whereas stable patients may undergo computed tomography, the standard examination protocol. The grade of liver injury alone does not accurately predict the need for operation, and nonoperative management is rapidly becoming popular for high-grade injuries. Hemodynamic instability with positive focused abdominal sonography for trauma and peritonitis is an indicator of the need for emergent operative intervention. The damage control concept is appropriate for the treatment of major liver injuries and is associated with significant survival advantages compared with traditional prolonged surgical techniques. Although surgical intervention for hepatic trauma is not as common now as it was in the past, current trauma surgeons should be familiar with the emergency surgical skills necessary to manage complex hepatic injuries, such as packing, Pringle maneuver, selective vessel ligation, resectional debridement, and parenchymal sutures. The present review presents emergency strategies and trends in the management of liver trauma.
关键词: liver trauma nonoperative management operative management
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 437-443 doi: 10.1007/s11684-016-0472-9
A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n=25) or 20 mg (n=38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in spleen size, 27.0% of which exhibited significant reduction (≥35%) at week 24. Significant improvement in debilitating constitutional symptoms, as assessed by MFSAF v2.0, was observed in patients treated with ruxolitinib. Ruxolitinib treatment was generally well tolerated by Chinese patients. Although the treatment was associated with an increase in certain adverse events (AEs) that were established as identified risks (anemia and thrombocytopenia), these AEs were considered manageable in this clinical setting. Ruxolitinib provided substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinese patients with MF.
Dynamic modelling and simulation of a post-combustion CO capture process for coal-fired power plants
《化学科学与工程前沿(英文)》 2022年 第16卷 第2期 页码 198-209 doi: 10.1007/s11705-021-2057-7
关键词: CO2 capture post-combustion capture simulation dominant factor
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《医学前沿(英文)》 2013年 第7卷 第3期 页码 301-305 doi: 10.1007/s11684-013-0283-1
Systemic inflammatory response following myocardial ischemia-reperfusion injury (IRI) to a specific organ may cause injuries. Ischemic post-conditioning (IPostC) has emerged as a promising method for myocardial protection against IRI both in experimental and in clinical settings. Enhancement of endogenous nitric oxide (NO) is one of the major mechanisms by which IPostC confers cardioprotection. However, the sensitivity of the diabetic heart to IPostC is impaired and the underlying mechanism is unknown. Adiponectin (APN) is an adipocyte-derived plasma protein with anti-diabetic and anti-inflammatory properties. Plasma levels of APN are decreased in obese subjects and in patients with type 2 diabetes. APN supplementation has been shown to increase NO production and attenuate myocardial IRI in normal (non-diabetic) animals. However, the effect of APN on myocardial injury in diabetic subjects, especially its potential in restoring the sensitivity of the diabetic heart to IPostC has not been investigated. In the current paper, we discussed the possible reasons why the myocardium of diabetic subjects loses sensitivity to IPostC and also highlighted the potential effectiveness and mechanism of APN in restoring IPostC cardioprotection in diabetes. This review proposes to conduct studies that may facilitate the development of novel and optimal therapies to enhance cardioprotection in patients with severe diseases such as diabetes.
关键词: adiponectin ischemic post-conditioning ischemia reperfusion injury diabetes
《工程管理前沿(英文)》 页码 82-95 doi: 10.1007/s42524-022-0233-1
关键词: pharmaceutical supply chain Internet of Things blockchain resilience post-pandemic era
Parametric study of hexagonal castellated beams in post-tensioned self-centering steel connections
Hassan ABEDI SARVESTANI
《结构与土木工程前沿(英文)》 2019年 第13卷 第5期 页码 1020-1035 doi: 10.1007/s11709-019-0534-6
关键词: finite element analysis hexagonal castellated beam parametric study post-tensioned self-centering steel connection steel moment-resisting frame
Special issue: Advancing supply chain resilience for excellence in the post-pandemic era
《工程管理前沿(英文)》 2023年 第10卷 第1期 页码 1-4 doi: 10.1007/s42524-022-0246-9
Integrated adsorption and absorption process for post-combustion CO
Gongkui Xiao, Penny Xiao, Andrew Hoadley, Paul Webley
《化学科学与工程前沿(英文)》 2021年 第15卷 第3期 页码 483-492 doi: 10.1007/s11705-020-1964-3
关键词: vacuum swing adsorption monoethanolamine post-combustion CO2 capture integrated process
基于拉索安全评估的普通斜拉桥和矮塔斜拉桥结构冗余度对比研究 Article
Khawaja Ali, Hiroshi Katsuchi, Hitoshi Yamada
《工程(英文)》 2021年 第7卷 第1期 页码 111-123 doi: 10.1016/j.eng.2020.07.021
本研究基于斜拉桥和矮塔斜拉桥的拉索安全性评估,为比较斜拉桥和矮塔斜拉桥提供了新的观点。由于二者都使用拉索,人们通常认为这两种类型的桥梁具有相同的结构。但是,国际桥梁设计标准规定了二者各自的拉索安全系数。为了纠正这一误解,本研究通过考虑各种异常因素和破坏因素(如过载、钢索损耗和钢索腐蚀)的影响,对在疲劳和极限状态下的拉索的安全系数进行了比较。本研究的主要目的是解释两种类型桥梁之间的结构差异,并通过采用确定性和非确定性方法来评估其结构冗余。为了实现这一目标,根据日本现行的拉索设计指南,本文建立了两座桥的三维模型。在达到桥梁模型的平衡状态之后,以参数化方式对拉索的不同安全系数进行了静态分析。最后,采用一阶可靠性方法和蒙特卡洛方法确定了拉索的可靠性指标。分析结果表明,在相同的荷载条件下,斜拉桥和矮塔斜拉桥在不同安全系数下具有不同的结构冗余度。此外,随着拉索的安全系数的增加,其结构上的冗余大大增加。
Interactions between remote ischemic conditioning and post-stroke sleep regulation
《医学前沿(英文)》 2021年 第15卷 第6期 页码 867-876 doi: 10.1007/s11684-021-0887-9
标题 作者 时间 类型 操作
Appendiceal inflammation affects the length of stay following appendicectomy amongst children: a myth
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期刊论文
Heterogeneous length-of-stay modeling of post-acute care residents in the nursing home with competing
期刊论文
Vortex-induced vibration of stay cable under profile velocity using CFD numerical simulation method
Wenli CHEN, Hui LI,
期刊论文
Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential
null
期刊论文
Dynamic modelling and simulation of a post-combustion CO capture process for coal-fired power plants
期刊论文
Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning
null
期刊论文
Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic
期刊论文
Parametric study of hexagonal castellated beams in post-tensioned self-centering steel connections
Hassan ABEDI SARVESTANI
期刊论文
Integrated adsorption and absorption process for post-combustion CO
Gongkui Xiao, Penny Xiao, Andrew Hoadley, Paul Webley
期刊论文